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Selected Publications

O'Brien D, Jones L, Good S, Miles J, Vijayabaskar M, Aston R, Smith C, Westhead D, Van Oosten-Hawle PC. 

A PQM-1-mediated response triggers transcellular chaperone signaling and regulates organismal proteostasis 

Cell Reports 23 3905-3919, 2018
DOI:10.1016/j.celrep.2018.05.093

Van Oosten-Hawle P, Bolon DNA, LaPointe P. The diverse roles of Hsp90 and where to find them 

Nature Structural&Molecular Biology 24 1-4, 2017
DOI:10.1038/nsmb.3359

O'Brien D, Van Oosten-Hawle PC. Regulation of cell-­nonautonomous proteostasis in metazoans 

Essays in Biochemistry 60 133-142, 2016
DOI:10.1042/EBC20160006

Tipping KW, Van Oosten-Hawle P, Hewitt EW, Radford SE Amyloid fibres: inert end-stage aggregates or key players in disease? 

Trends in Biochemical Sciences 40 719-727, 2015
DOI:10.1016/j.tibs.2015.10.002

van Oosten-Hawle P, Morimoto RI Organismal proteostasis: role of cell-nonautonomous regulation and transcellular chaperone signaling 

Genes&Development 28 1533-1543, 2014
DOI:10.1101/gad.241125.114

van Oosten-Hawle P, Porter R, Morimoto R Regulation of Organismal Proteostasis by Transcellular Chaperone Signaling 

Cell 153 1366-1378, 2013
DOI:10.1016/j.cell.2013.05.015