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  • van Oosten-Hawle P. A new chink in cancer's armor: Unleashing cell death by selective PP5 inhibition. Cell Chem Biol. 2023 Oct 19;30(10):1186-1188. doi: 10.1016/j.chembiol.2023.09.002. PMID: 37863031.

  • van Oosten-Hawle, P. Smelling your way to longevity. Nat. Rev. Mol Cell Biol. 2023 Sep 11. doi: 10.1038/s41580-023-00664-1. Online ahead of print.PMID: 37697008

  • van Oosten-Hawle P. Exploiting inter-tissue stress signaling mechanisms to preserve organismal proteostasis during aging.Front Physiol. 2023 Jul 4;14:1228490. doi: 10.3389/fphys.2023.1228490. eCollection 2023.PMID: 37469564 

  • Miles, J., Townend, S., Milonaityte, D., Smith, W., Hodge, F., Westhead, D.R., van Oosten-Hawle, P. Transcellular chaperone signaling is an intercellular stress response distinct from the HSF-1 mediated heat shock response. PLoS Biol. 2023 Feb 13;21(2):e3001605.

  • van Oosten-Hawle, P. Organismal Roles of Hsp90. Biomolecules 2023, 13, 251.

  • van Oosten-Hawle P, Backe SJ, Ben-Zvi A, Bourboulia D, Brancaccio M, Brodsky J, Clark M, Colombo G, Cox MB, De Los Rios P, Echtenkamp F, Edkins A, Freeman B, Goloubinoff P, Houry W, Johnson J, LaPointe P, Li W, Mezger V, Neckers L, Nillegoda NB, Prahlad V, Reitzel A, Scherz-Shouval R, Sistonen L, Tsai FTF, Woodford MR, Mollapour M, Truman AW. Second Virtual International Symposium on Cellular and Organismal Stress Responses, September 8-9, 2022. Cell Stress Chaperones. 2023 Jan;28(1):1-9. doi: 10.1007/s12192-022-01318-5. Epub 2023 Jan 5. PMID: 36602710; PMCID: PMC9877255.


  • Ulamec SM, Maya-Martinez R, Byrd EJ, Dewison KM, Xu Y, Willis LF, Sobott F, Heath GR, van Oosten Hawle P, Buchman VL, Radford SE, Brockwell DJ. Single residue modulators of amyloid formation in the N-terminal P1-region of α-synuclein. Nat Commun. 2022 Aug 25;13(1):4986. doi: 10.1038/s41467-022-32687-1. PMID: 36008493; PMCID: PMC9411612.

  • Hodge, F., Bajuszova, V., van Oosten-Hawle, P. The Intestine as a Lifespan- and proteostasis promoting signaling tissue. Front Aging, 2022 Jun 2;3:897741.


  • Good SC, Dewison KM, Radford SE, van Oosten-Hawle P. Global Proteotoxicity Caused by Human β2 Microglobulin Variants Impairs the Unfolded Protein Response in C. elegans. International Journal of Molecular Sciences. 2021; 22(19):10752.

  • FASEB Catalyst Conference on Extracellular and Organismal Proteostasis in Health and DiseaseChen Lior, Francesca Hodge, Evandro A. De-Souza, Dimitra Bourboulia, Stuart K. Calderwood, Della David, D. Allan Drummond, Adrienne Edkins, Richard I. Morimoto, Veena Prahlad, Oded Rechavi, Lea Sistonen, Mark Wilson, R. Luke Wiseman, Maurizio Zanetti, Rebecca Taylor, Ruth Scherz-Shouval, Patricija van Oosten-Hawle. FASEB Journal 2021 Jun;35(6):e21631.

  • First Virtual International Congress on Cellular and Organismal Stress Responses, November 5-6, 2020.van Oosten-Hawle P, Bergink S, Blagg B, Brodsky J, Edkins A, Freeman B, Genest O, Hendershot L, Kampinga H, Johnson J, De Maio A, Masison D, Morano K, Multhoff G, Prodromou C, Prahlad V, Scherz-Shouval R, Zhuravleva A, Mollapour M, Truman AW. Cell Stress Chaperones. 2021 Mar;26(2):289-295.


  • Lackie, R.E., Marques-Lopes, J., Ostapchenko, V.G., Good, S., Choy, W., van Oosten-Hawle, P., Pasternak, S.H., Prado, V.F., and Prado, M.A.M., (2020) Acta Neuropathologica Communications. 2020 Aug 21;8(1):143.

  • Miles, J., van Oosten-Hawle P. Tissue-specific RNAi tools to identify components for systemic stress signaling. Journal of Visual Experiments (JOVE) (2020) May 16;(159).

  • Doherty,CPA; Ulamec S.M., Maya-Martinez R., Good, S., Makepeace, J., Khan, N.G., van Oosten-Hawle, P., Radford, S.E., Brockwell, D.J. A short motif in the N-terminal region of alpha-synuclein is critical for both aggregation and function (2020), Nature Structural & Molecular Biology. 2020 Mar;27(3):249-259

  •  Jones, L.M., Chen Y., van Oosten-Hawle, P. Redefining proteostasis transcription factors in organismal stress responses development, metabolism, and health. Biological Chemistry 2020; 401(9):1005-1018.

  • Good, S., van Oosten-Hawle, P. Caenorhabditis elegans as a model organism for protein homeostasis diseases, Book Chapter, Protein Homeostasis Diseases, Mechanisms and Novel Therapies, 2020, p41-69.



  • Miles, J., Scherz-Shouval R., and van Oosten-Hawle, P. (2019) Expanding the organismal proteostasis network: Linking systemic stress signalling with the innate immune response. Trends in Biochemical Sciences, 2019 Jul 11. pii: S0968-0004(19)30142-2


  • Duplication of hsp-110 is implicated in differential success of Globodera species under climate change.

       Jones LM, Eves-van den Akker S, van Oosten Hawle P, Atkinson HJ, Urwin PE.

       Mol. Biol. Evol. (2018) Jun 28

  • O'Brien D, Jones L, Good S, Miles J, Vijayabaskar M, Aston R, Smith C, Westhead D, Van Oosten-Hawle PC. 

       A PQM-1-mediated response triggers transcellular chaperone signaling and regulates organismal proteostasis 

      Cell Reports 23 3905-3919, 2018 DOI:10.1016/j.celrep.2018.05.093


  • Van Oosten-Hawle P, Bolon DNA, LaPointe P. The diverse roles of Hsp90 and where to find them Nature Structural&Molecular Biology 24 1-4, 2017 DOI:10.1038/nsmb.3359


  • O'Brien D, Van Oosten-Hawle PC. Regulation of cell-­nonautonomous proteostasis in metazoans Essays in Biochemistry 60 133-142, 2016 DOI:10.1042/EBC20160006


  • Tipping KW, Van Oosten-Hawle P, Hewitt EW, Radford SE Amyloid fibres: inert end-stage aggregates or key players in disease? Trends in Biochemical Sciences 40 719-727, 2015 DOI:10.1016/j.tibs.2015.10.002


  • van Oosten-Hawle P, Morimoto RI Organismal proteostasis: role of cell-nonautonomous regulation and transcellular chaperone signaling Genes&Development 28 1533-1543, 2014 DOI:10.1101/gad.241125.114


  • van Oosten-Hawle P, Porter R, Morimoto R Regulation of Organismal Proteostasis by Transcellular Chaperone Signaling 

       Cell 153 1366-1378, 2013DOI:10.1016/j.cell.2013.05.015

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